Ghana coach Kwesi Appiah says the time has come to end the dominance of Cameroon over his country in the Africa Cup of Nations.
The Black Stars have confronted the Indomitable Lions four times from 1982 and the best they have achieved is two group draws while suffering two semi-final defeats.
"We are going to give Cameroon a really good game and I am sure we will emerge victorious," said the coach in his second spell as Ghana coach.
Defending champions Cameroon will start as slight favourites to win the Group F clash in Ismailia Saturday having been the more impressive performers earlier this week.
Cameroon scored twice in three minutes to end the resistance of Guinea-Bissau and win 2-0 while Ghana had John Boye red-carded as they were held 2-2 by Benin.
Appiah is not overly concerned with the two dropped points against lower-ranked Benin because Ghana are traditionally slow starters at the Cup of Nations.
They always recover and boast a record of six consecutive top-four finishes from 2008, including finishing runners-up twice.
He was upset by the dismissal of veteran Boye, believing his time wasting should have earned a verbal warning rather than a second yellow card.
Cameroon centre-back Ambroise Oyongo, one of four starters against Guinea-Bissau who were part of the 2017 title-winning team, says they must improve against Ghana.
"We have to raise our game against Ghana. We did not start with a win in 2017 but this time we did and I believe that is a good omen going forward in the competition."
What is the kick-off time of Ghana vs Cameroon?
The match is scheduled for 17:00 GMT on June 29.
What is the head to head record of Ghana vs Cameroon?
Eight previous meetings have produced three Ghana wins, three draws and two Cameroon victories.
Team News: Who is available, injured or suspended for Ghana vs Cameroon?
Cameroon: Clarence Seedorf is expected to start the same team against Ghana after they beat Guinea-Bissau 2-0 in their first match.
Ghana: Kwesi Appiah will make changes to the team as John Boye and Thomas Agyepong have been ruled out due to suspension and injury, respectively.
Skipper Andre Ayew will start after recovering from a knock sustained in the Benin match.
Predicted starting XI
Cameroon: Andre Onana – Ambroise Onyongo, Ngadeu-Ngadjui, Yaya Banana, Dawa Tchakonte – Anguissa, Mandjeck, Djoum – Ekambi, Choupou-Moting, Bassogog.
Ghana: Richard Ofori – Andy Yiadom, Baba Rahman, Kassim Nuhu, Jonathan Mensah - Afriyie Acquah, Kwadwo Asamoah, Thomas Partey - Andre Ayew, Jordan Ayew, Samuel Owusu.