Three Ghanaian players Dennis Appiah, Mohammed Dauda and Emmanuel Sowah are expected to leave Anderlecht during the January transfer window.
According to Het Nieuwsblad, twelve players have to leave to make room for reinforcements.
Appiah, who is a right back, has played only six times this season while Sowah has been with the reserve side.
Striker Dauda will drop the pecking order if the club sign in a new striker.
The 20-year-old is reported to be on the wish lists of some European sides is already considering a move elsewhere for unlimited game time.
He has played four appearances this season.