The first leg of the clash will be played in Dormaa between 6-7 March
Ghana Premier League champions, Aduana Stars will face Algerian side, ES Setif in the final qualifying round of the 2018 CAF Champions League.
The Fire Boys defeated Al Tahaddy 2:0 in the second league on Wednesday to progress 2-1 on aggregate.
However, the Algerian side also advanced against Central African Republic side Olympic Real de Bangui thanks the 6-0 first leg win at home.
The first leg of the clash will be played in Dormaa between 6-7 March and the return leg at the Stade 8 Mai 1945 in the city of Setif.
Aduana Stars are now Ghana's only representatives in Africa following Kotoko's exit from the CAF Confederation Cup.
The Porcupine Warriors lost 6-7 on penalties after the two- legged tie ended 1-1 in regulation time.
No Ghanaian side has won a continental title since Hearts of Oak won the Confederation Cup in 2004
