Two children were burnt to death when fire gutted some wooden structures at Old Fadama in Accra.
Emmanuel Kofi, 12, and Kofi Owusu, eight, died Wednesday when a structure in which they were sleeping was razed down by the fire.
The two children are said to have cried for help but the fire was so intense that no one could enter their room to save them.
Their bodies have since been deposited at the Korle-Bu mortuary for autopsy.
The fire, which began around 9:30 p.m., destroyed 20 wooden structures, some of which were one-storey buildings, cash and the personal belongings of occupants.
A bread seller, Adjoa Mercy, claimed she survived the fire only because she was thrown down from the top floor of the one-storey structure by her landlord.
She said she was awoken from her sleep by the continuous shouts of her name and looked perplexed upon seeing the structure in flames.
She said the landlord, who was close by, threw her off the structure to the ground.
The James Town District Crime Officer, DSP Alex Asamoa-Frimpong, confirmed the incident.
He said before personnel of the Ghana National Fire Service could get to the scene, all the 20 structures had been destroyed.