Kwadwo Asamoah and Daniele Rugani will have tests tomorrow after the Juventus pair both suffered sprained knees.
The duo went off during their 1-0 Serie A victory away to Palermo.
Rugani had started the match and limped off, while Asamoah was a late substitute who lasted only 20 minutes.
“Kwadwo Asamoah and Daniele Rugani underwent medical tests following tonight’s match away in Palermo, which revealed sprains to their right knees,” read a statement.
“Both players will undergo more specialist checks tomorrow at J-Medical.”
Initial reports suggest Rugani’s condition is nothing to be concerned about, but Asamoah was spotted in tears and he could be in for a lengthy lay-off.
It would be a big problem for the 27-year-old Ghana international, who has dealt with a series of injuries in recent years.