Berekum Chelsea beat Liberia's LISCR 2-0 in their Caf Champions League preliminary round first leg tie on Sunday.
Defender Eric Agyemang connected a free-kick in the second half to register the club's first continental goal as they make their debut.
New signing Jordan Opoku came off the bench to double the lead on 80 minutes at the Antoinette Tubman Stadium in Monrovia.
Chelsea will host the return leg will at the Golden City Park in a fortnight the winner over both legs advancing to play Wydad Athletic Casablanca of Morocco.