Medeama will travel to DR Congo on Thursday ahead of their CAF Confederation group opener against giants TP Mazembe.
The two-time Ghanaian FA Cup holders will take on the five-time African champions in Lubumbashi on Sunday.
The Mauve and Yellows will take on Techiman City in an outstanding Premier League fixture, which has been rained of on two occasions on Tuesday.
The team will then fly out to DR Congo two days later for the big clash against the African powerhouse in their opening group A clash.