Assistant Black Stars coach Kwesi Appiah has confirmed that two changes have been made to the squad ahead of their game against Saudi Arabia this week.
Bernard Kumordzi and Karim Alhassan have been drafted into Ghana's squad following injuries to John Mensah and Matthew Amoah.
The Black Stars play Saudi Arabia in Dubai on Wednesday in an international friendly.
Mensah picked up a shoulder injury whiles playing for Sunderland last week while Amoah suffered an injury in NAC Breda's 2-1 victory against FC Twente as he got the winner for Breda on Saturday.
Both players were part of the initial 19-man squad announced last week.
Ghana squad: Goalkeepers: Richard Kingson (Blackpool, England), Sammy Adjei (Hearts of Oak, Ghana)
Defenders: John Paintsil (Fulham, England) Samuel Inkoom (Basel, Switzerland) Harrison Afful (Esperance, Tunisia) Lee Addy (Red Star Belgrade, Serbia) David Addy (Academica Coimbra, Portugal) Jonathan Mensah (Granada, Spain) Isaac Vorsah (Hoffenheim, Germany) Karim Alhassan (Hearts of Oak, Ghana)
Midfielders: Anthony Annan (Rosenborg, Norway), Emmanuel Agyemang-Badu (Udinese, Italy), Kwadwo Asamoah (Udinese, Italy) Andre Ayew (Marseille, France) Kevin-Prince Boateng (AC Milan, Italy) Bernard Kumordzi (Panionios FC, Greece)
Attackers: Asamoah Gyan (Sunderland, England), Emmanuel Clottey (Berekum Chelsea, Ghana) Quincy Owusu-Abeyie (Malaga, Spain)