He attended St. Peters mission school and calvary Intnl J.S.S at Medina - Accra and finally to Koforidua Sec. Tech. Inst. He started his colts football with Medina fields Masters in 1999-2001, where he played 24 matches and scored 20 goals with which he won the Goal King for that season.
Prince was invited to play for the National Under 17 side of Ghana where he performed creditably well in 2001 and was letter promoted to the National under 20 side of Ghana's football in the year 2004.
Prince splendid performance in the national team won him a contract with one of the prestigious premier clubs in Ghana, Accra Hearts of Oaks.
The lanky striker and 2004/05 goalking was transfered in January 2006 to Al-Ettihad club in Saudi Arabia but was loan in September to Al-Shabbab in UAE.
He joined Saudi Arabian football club Al-Ettifaq based in Dammam in July 2007 in a deal worth $1.2million
JUne 2009: Ghana international striker Prince Tagoe has joined German Bundesliga club Hoffenheim on a free transfer and a three-year contract