Vice President of the United States of America, Kamala Harris and her husband are expected in town later today as she begins her tour of Africa.
She becomes the fourth top White House official - rank of president - to visit Ghana under the Fourth Republic.
Bill Clinton visited during Jerry John Rawlings era, Kufuor received President George Bush and the last such visit was when Barack Obama, fresh from his 2008 victory chose Ghana as his first African destination on July 10, 2009.
President John Evans Atta Mills, his vice John Dramani Mahama and his two predecessors were present at events during Obama's high-profile and widely celebrated visit.
Obama arrived at the Kotoka International Airport (KIA) whith his wife and two daughters. He later visited the Cape Coast castle and also delivered an address before Parliament.
Read the Ghana News Agency's full report of his arrival
Obama begins historic visit to Ghana
US President Barack Obama arrived in Accra on Friday night to a warm proverbial Ghanaian "Akwaaba" to begin his momentous two-day visit, his first to a sub-Saharan African nation since assuming office.
The US Presidential jet, Air Force One, which is making its third call to the Kotoka International Airport, after President Bill Clinton (1998) and President George W. Bush (2008), touched down around 2105 hours.
Moments later, a brimming President Obama accompanied by his wife Michelle, their two daughters, Malia and Sasha, and a 50-member delegation, came out of the aircraft to euphoric cheers. There were moving scenes at the airport as President John Evans Atta Mills, resplendent in a smock and his wife Naadu, in a wax kaba cloth, approached the gangway to receive the US first family. Nadei Okaikoi, eight-and-half years old class three pupil of ALSYDS Academy, presented a bouquet to President Obama.
The US president and his wife and children, full of smiles, were introduced to the welcoming party which included politicians from across the political divide, including Nana Akufo-Addo, the losing presidential candidate of the New Patriotic Party (NPP).
The festive atmosphere was enhanced by a dancing troupe from the National Dance Company whose Coordinator, Mr George Lamptey, said they were performing heraldic dances meant to welcome the august visitor and his family and make them feel at home.
President Obama savoured the moment by taking a few steps to the "frontonfron" beat and encouraged his wife, who was then walking with Mrs Mills, to join in dancing to the beat.
A large crowd of youth wearing Obama T-shirts defied intermittent showers as they lined parts of the street to the airport to welcome the US President.
President Obama would then be hosted to a big breakfast for about 300 guests, including former presidents Jerry John Rawlings and Mr. John Agyekum Kufuor, as well as the presidential contestants of the 2008 elections, leadership of the religious bodies, traditional councils, civil society and business communities.
President Obama would then pay a brief visit to the La General Hospital briefly in Accra, before moving to the Accra International Conference Centre (AICC), where Parliament would be convened to hear his formal address.
While at the AICC, President Obama would make a major policy statement that is expected to redefine America's relationship with Africa.
In line with his earlier pronouncements that his presidency would seek to assist Africa to reach the point where its citizens would be proud to stay and work on the continent, he would be expected, through his policy statement in Ghana, to set the tone for equal partnership between America and Africa, just like he has done elsewhere.
The major address ends President Obama's official activities in Accra.
He then moves to Cape Coast, the capital city of the Central Region, where he would be welcomed by the Ghana's own Obama, Vice President John Dramani Mahama and given a private tour of the Cape Coast Castle.
President Obama and his wife would be expected to go through the emotional experience at the gate of no return, after which he would call on chiefs and people of Cape Coast and Mrs. Obama would be enstooled a Queen mother.
He would then depart for the KIA where he and his host would give brief remarks before he boards Air Force One back to the United States. 10 July 09