Holders of the the National Science and Maths Quiz Prempeh College will attempt to begin the retention journey as they face Accra Academy and Islamic SHS in the quarterfinals of the competition.
The quest for supremacy and bragging rights will be determined after four rounds of the competition.
As it stands West Africa Senior High School, St. Peters High School as well as Mfantsipim Senior High School have all sailed through to the semifinals.
Watch a livestream of the 2018 National Science and Maths Quiz here: