Albert Adomah has been forced to withdraw from the Ghana squad ahead of next month's 2014 World Cup qualifiers against Lesotho and Zambia.
The Bristol City attacker is out after suffering a knee injury.
He has been replaced by debutant, Solomon Asante of Berekum Chelsea.
Asante will join the Black Stars when they start a non-residential camp in Accra on 21st May, 2012.
The squad will be pruned before the team departs to Kumasi on 27th May ahead of the match against Lesotho on 1st June, 2012.
Ghana face Lesotho in Kumasi for Appiah's first game before they play Zambia on June 9 in Ndorla.
Ghana Squad
Goalkeepers: Adam Kwarasey (Stromsgodset, Norway), Robert Dabuo (Wa All Stars), Daniel Adjei (Liberty Professionals), Ernest Sowah (Berekum Chelsea)
Defenders: Samuel Inkoom (Dnipro, Ukraine), Daniel Opare (Standard Liege, Belgium), Harrison Afful (Esperance, Tunisia), Richard Kissi Boateng (Berekum Cheslea), Masawudu Alhassan (Genoa, Italy), John Boye (Rennes, France), Lee Addy (Dalian Aerbin, China), Daniel Addo (Zorya Luhansk, Ukraine) Rashid Sumaila (Dwarfs), Jerry Akaminko (Manisaspor, Turkey), Isaac Vorsah (Hoffenheim, Germany)
Midfielders: Anthony Annan (Vitesse Arnhem, Netherlands), Derek Boateng (Dnipro, Ukraine), Emmanuel Agyemang Badu (Udinese ,Italy), Rabiu Mohammed (Evian, France) Richard Mpong (Medema) Solomon Asante (Berekum Chelsea), Christian Atsu (Rio Ave, Portugal), Ishamel Yartey, (Servette, Switzerland), Sulley Muntari (AC Milan, Italy), Kwadwo Asamoah (Udinese, Italy).
Forwards: Jordan Ayew (Marseille, France), Dominic Adiyiah (Arsenal Kyiv, Ukraine), Ben Acheampong (Kotoko), Emmanuel Baffour (New Edubiase), Emmanuel Clottey (Berekum Chelsea).
