Medeama coach Samuel Boadu has been forced to make three replacements ahead of their Ghana Premier League showdown at Dreams FC following an injury to two key players while one has been dropped.
Defenders Ali Ouattara and Philip Osei who have been impressive in their blistering start to the season did not make the trip after picking up an injuries in their 1-0 win over Asante Kotoko on Wednesday.
Midfielder Joseph Cudjoe has been dropped and has been replaced by Jasper Nimo.
Defenders Rashid Alhassan and Fatawu Sulemana could make their Premier League debut after being named in an 18-man squad.
The Mauve and Yellows travel to a familiar territory seeking to maintain their impressive start to the campaign.
But they will face their biggest trip of the campaign against a rejuvenated Dreams FC side who have equally been impressive so far.
The Theater of Dreams is always a difficult hunting ground for any opponents after dropping just one point so far against Legon Cities.
Medeama drew 2-2 at the same venue in their last meeting on May 22, 2016 after coming from two goals down to sniff a point.
However, the dynamics are different with the two teams in fine shape ahead of the big showdown.
Medeama 18-man squad against Dreams FC
Eric Ofori Antwi (GK), Yaw Ansah (GK), Samuel Appiah, Meshack Odoom, Fatawu Sulemana, Daniel Egyin, Alhassan Rashid, Ibrahim Yaro, Richard Boadu, Michael Yeboah, Jasper Nimo, Agyei Boakye, Isaac Agyenim Boateng, Prince Opoku-Agyemang, Nana Kofi Babil, Ebenezer Ackahbi, Joseph Tetteh Zutah and Kwasi Donsu.