UG Prof Boima details holistic pathways to precision kidney care in Africa

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• Kelewele 2 days ago

  Israeli Researchers were the first to connect the link between Chronic Kidney Disease (CKD and its prevalence among West African people in general, not specifically Akans or Moshi. In the simplest explanation, they discovered ...
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  Israeli Researchers were the first to connect the link between Chronic Kidney Disease (CKD and its prevalence among West African people in general, not specifically Akans or Moshi. In the simplest explanation, they discovered that a gene that protects us against the Tsetse Fly unfortunately has a “side effect” that negatively impacts our kidneys. The double variant is more aggressive and has been tracked to black populations in faraway regions with West African migration patterns, example the USA and the Caribbean countries.
  
  First, it is a well-established research finding with broad implications for most black people, except those from Central, East and Southern Africa. Second, this is not new and the Prof should not attempt to plagiarise the hard work of others by adding the Akan twist.
  Here’s the reference for anyone who needs to follow the story:
  
  The Israeli team that led this discovery was based at the Technion-Israel Institute of Technology and Rambam Health Care Campus in Haifa.Led by Dr. Karl Skorecki (and including researchers like Dr. Shay Tzur and Dr. Doron Behar), the team published a landmark study in 2010 identifying missense mutations in the \(APOL1\) gene as the driving cause of kidney disease risk in African Americans.For further reading on their findings, you can explore their population genetics paper published in Science.

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• Kelewele 2 days ago

  Multiethnic prevalence of the APOL1 G1 and G2 variants among the Israeli dialysis population
  Dror Ben-Ruby 1,2, Danit Atias-Varon 3,4, Maayan Kagan 5,6,7, Guy Chowers 8,9,10, Omer Shlomovitz 11,12,13, Keren Slabodnik-Kaner 1 ...
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  Multiethnic prevalence of the APOL1 G1 and G2 variants among the Israeli dialysis population
  Dror Ben-Ruby 1,2, Danit Atias-Varon 3,4, Maayan Kagan 5,6,7, Guy Chowers 8,9,10, Omer Shlomovitz 11,12,13, Keren Slabodnik-Kaner 14,15, Neta Mano 16,17,18, Shany Avayou 19, Yariv Atsmony 20,21,22, Dana Levin 23, Edo Dotan 24,25, Ronit Calderon-Margalit 26, Alla Shnaider 27,28, Yosef S Haviv 29,30, Ohad S Birk 31,32, Noam Hadar 33, Yair Anikster 34,35, Noa Berar Yanay 36,37, Gil Chernin 38, Etty Kruzel-Davila 39,40, Pazit Beckerman 41,42, Benaya Rozen-Zvi 43,44, Gabriel T Doctor 45, Horia C Stanescu 46, Revital Shemer 47, Elon Pras 48,49, Haike Reznik-Wolf 50,51, Ayelet Hashahar Nahum 52, Dan Dominissini 53,54,55, Karl Skorecki 56,57,58,#, Asaf Vivante 59,60,61,62,#,✉
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  PMCID: PMC11803305 PMID: 39927257
  
  ABSTRACT
  Background and hypothesis
  The two apolipoprotein L1 (APOL1) variants, G1 and G2, are common in populations of sub-Saharan African ancestry. Individuals with two of these alleles (G1 or G2) have an increased risk for a spectrum of non-diabetic chronic kidney diseases. However, these variants are typically not observed outside of populations that self-identify as current continental Africans or having clear recent African ancestry such as, most notably, African Americans, and other large population groups in the Americas and several European countries. We hypothesized that the diverse ethnic groups within the Israeli population may exhibit varying levels of recent African ancestry. Therefore, it is plausible that APOL1 risk alleles might be present even in individuals who do not self-identify as being of sub-Saharan African descent.

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• Donatus 2 days ago

  Ghanaweb, are you talking about "cure" or "care"?

  Ghanaweb, are you talking about "cure" or "care"?

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• Stan 2 days ago

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