One person is feared dead while several others have sustained varying degrees of injuries at Somanya in the eastern region.
The victims who are believed to be supporters of the National Democratic Congress were travelling from Koforidua to Apeguso in the Asuogyaman District for the party's primaries.
An eye witness, Okatakyie Frimpong Manso explains that one of the tyres of the Toyota Hiace bus they were travelling with burst somersaulting several times in the process.
He says the surviving victims of the accident are on admission at a hospital in Somanya.