Elmina Sharks will square off against regional-rivals Ebusua Dwarf at Nduom Sports Stadium on Wednesday.
The Sea Animals will seek to make amends with all three points after Karela United ended their unbeaten run at Cosby Awuah Memorial Park on Sunday.
Meanwhile the Crabs come into match at the back of 2-1 win over Inter Allies at the Cape Coast stadium on matchday nine.
The match promises to be a thrilling one as the coastal rivals battle it out for honor and bragging rights.